Hippocampal Cofilin and CFL1 gene variants are linked to Alcohol Use Disorder phenotypes.

ABSTRACT: Alcohol use disorder (AUD) is characterized by pathological motivation to consume alcohol and cognitive inflexibility, leading to excessive alcohol seeking and use. In this study, we investigated the molecular correlates of impaired extinction of alcohol seeking during forced abstinence using a mouse model of AUD in the automated IntelliCage social system. This model distinguished AUD-prone and AUD-resistant animals based on the presence of ≥2 or <2 criteria of AUD, respectively. We used RNA sequencing to identify genes differentially expressed in the hippocampus, a brain region implicated in alcohol motivation, seeking during abstinence, and cognitive inflexibility. Our findings revealed differences in the hippocampal genes linked to the actin cytoskeleton and synaptic function, including

SUBMITTER: Salamian A 

PROVIDER: S-EPMC12916304 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature