Associations of polygenic risk scores for major depression and depression severity: an investigation of 105 623 individuals with 16 years follow-up.

ABSTRACT: Genetic risk could be informative for identifying individuals at risk of depression with severe outcomes. With the novel approach of combined health care registries and self-report measures related to depression, the authors aimed to identify the impact of polygenic risk scores (PRS) for major depression on self report measures and a diagnosis of depression across diagnostic thresholds. The study sample comprised participants from the Norwegian Mother, Father and Child Cohort Study with linked information of depression diagnoses during 2006-2022 from health registries. Linear and logistic models were used to estimate the associations between PRS for major depression and self-reported measures related to depression (Symptom Checklist- 5, Satisfaction With Life Scale, Rosenberg Self-Esteem S

SUBMITTER: Haram M 

PROVIDER: S-EPMC12916310 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature