Comprehensive characterization of nonlinear viscoelastic properties of arterial tissues using guided-wave optical coherence elastography.

ABSTRACT: The mechanical properties of arterial walls are critical for maintaining vascular function under pulsatile pressure and are closely linked to the development of cardiovascular diseases. Despite advances in imaging and elastography, comprehensive characterization of the complex mechanical behavior of arterial tissues remains challenging. Here, we present a broadband guided-wave optical coherence elastography (OCE) technique, grounded in viscoelasto-acoustic theory, for quantifying the nonlinear viscoelastic, anisotropic, and layer-specific properties of arterial walls with high spatial and temporal resolution. Our results reveal a strong stretch dependence of arterial viscoelasticity, with increasing prestress leading to a reduction in tissue viscosity. Under mechanical loading, the adventi

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12916319 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature