Changes in apolipoproteins following ingestion of a beverage delivering <i>β</i>-hydroxybutyrate: results from a randomized placebo-controlled trial.

ABSTRACT:

Background

Apolipoproteins play important roles in the metabolism of triglyceride-rich lipoproteins. Ketone monoester β-hydroxybutyrate (KEβHB) has been shown to reduce the circulating levels of remnant cholesterol and triglycerides. However, the mechanisms behind this action remain unknown.

Aim

To investigate the effect of KEβHB supplementation on apolipoproteins and to study whether circulating levels of triglycerides play a role in this effect.

Methods

The study was a randomized placebo-controlled trial, registered at https://www.clinicaltrials.gov/ (NCT03889210). It included 18 adults (12 men and 6 women) with prediabetes (defined as per the American Diabetes Association criteria). Following an overnight fast, participants ingested a KEβHB or a placebo beve

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12916354 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature