Global trends of peripheral immune tolerance research: a bibliometric and visualization analysis.

ABSTRACT:

Background

Peripheral immune tolerance is a key mechanism for maintaining immune homeostasis and preventing autoimmune responses. Although numerous studies have explored its molecular and cellular basis, a comprehensive and systematic overview of the field is still lacking. This study aims to elucidate the global research landscape of peripheral immune tolerance through bibliometric analysis.

Methods

Publications related to peripheral immune tolerance from 1989 to 2025 were retrieved from the Web of Science Core Collection and Scopus databases. After removing duplicates, a total of 3,098 papers were included. CiteSpace, VOSviewer, RStudio Biblioshiny, and OriginPro were used for systematic analysis, allowing effective identification of research trends and emerging topics.

SUBMITTER: Kong S 

PROVIDER: S-EPMC12916357 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature