Evaluation of biochemical, histopathological, hematological, and genotoxic effects of some indigenous weed plant extracts in albino rats toward a natural and safe alternative to synthetic insecticides.

ABSTRACT:

Introduction

The indiscriminate use of pesticides poses a significant risk to human health and the environment. Plant-based biopesticides offer an alternative to insecticides for integration into insect pest management programs.

Methods

The current study assessed the toxicological effects of leaf extracts from indigenous weed plants, Chenopodium murale and Achyranthes aspera, in albino rats, Rattus norvegicus. The extract-mixed diet was fed in three different doses (100 ppm, 150 ppm, and 250 ppm) for 28 days, while the Cypermethrin insecticide was used as a reference insecticide at the same dose levels. Samples from liver and kidney tissues were collected for histopathological study, and the blood serum was obtained for biochemical assay.

Results and

SUBMITTER: Zahoor MA 

PROVIDER: S-EPMC12916361 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature