Impact of rice wine-steamed <i>Cistanche deserticola</i> polysaccharides on intestinal flora and immunological modulation in immunosuppressive mice induced by cyclophosphamide.

ABSTRACT:

Introduction

Cistanche deserticola, a valued medicinal and food homologous material in traditional Chinese medicine, is renowned for enhancing immunity and protecting the mucosal barrier, with polysaccharides considered its primary active components. Raw material requires processing for optimal efficacy, yet most studies focus on unprocessed polysaccharides (RCP). This study investigates how traditional rice-wine processing alters the polysaccharides (WCP) and their immunomodulatory effects.

Methods

The physicochemical properties of RCP and WCP were characterized using SEM, HPGPC, FT-IR, and GC-MS. Immunosuppressed mice induced by cyclophosphamide (CTX) were used as an in vivo model. Immune function was assessed via body weight, organ indices, serum immunoglobu

SUBMITTER: Lian J 

PROVIDER: S-EPMC12916368 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature