TNFRSF11B modulates Marek's disease virus infection by regulating apoptosis in chicken embryo fibroblasts.

ABSTRACT:

Introduction

Marek's disease, caused by the oncogenic Marek's disease virus (MDV), remains a major threat to poultry production. Host immune responses and apoptosis pathways play critical roles in MDV pathogenesis, yet the underlying mechanisms are not fully understood.

Methods

Chicken embryo fibroblasts (CEF) were treated with poly I:C to assess its effect on MDV infection, followed by transcriptome profiling to identify differentially expressed genes. Functional assays using siRNA knockdown and overexpression of TNFRSF11B were performed to evaluate its impact on viral infection and apoptosis.

Results

Poly I:C treatment significantly reduced MDV infection in CEF. Transcriptome analysis identified 274 DEGs, among which TNFRSF11B was notably downregulated. Consistently

SUBMITTER: Zheng G 

PROVIDER: S-EPMC12916386 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature