Prognostic value of admission NHHR for functional recovery in acute ischemic stroke.

ABSTRACT:

Background

Early risk stratification in acute ischemic stroke (AIS) is critical for guiding management and improving outcomes. The ratio of non-high-density lipoprotein to high-density lipoprotein cholesterol (NHHR) represents the equilibrium between pro-atherogenic and anti-atherogenic lipoproteins, potentially capturing both lipid metabolism and inflammatory status, but its prognostic value in AIS remains unclear.

Methods

We retrospectively analyzed 812 first-ever AIS patients. Admission NHHR was calculated from routine lipid panels. The study's main outcome was 90-day functional status, determined using the modified Rankin Scale. Associations with NHHR were examined through multivariable logistic regression, quartile analyses, restricted cubic spline (RCS) modeling, and s

SUBMITTER: Kong X 

PROVIDER: S-EPMC12916411 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature