Identifying affective state via clustering of temporal variability in limbic activity and mediating role of negative emotion.

ABSTRACT: The amygdala and nucleus accumbens are associated with emotion management in humans. Emotions play a central role in conditions such as depression and anxiety, where emotional states characterize the core symptoms. Effective emotion regulation can alleviate these symptoms, which highlights the importance of amygdala and nucleus accumbens in mental health. Functional magnetic resonance imaging studies that incorporate temporal characteristics of brain regions are limited. Therefore, this study examined the association of temporal variability of the limbic region, specifically the amygdala and nucleus accumbens, with worsening depressive or anxiety states mediated by negative emotions. The study included 1,080 healthy subjects from the Human Connectome Project dataset, and nine functional ne

SUBMITTER: Lee DY 

PROVIDER: S-EPMC12916492 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature