Impact of acute anorexia nervosa and of short-/long-term recovery after refeeding on the hormonal profiles of activin A, GDF-15 and follistatins.

ABSTRACT: Anorexia Nervosa (AN) is a severe eating disorder characterized by endocrine and metabolic abnormalities. In this study, we evaluated how the concentrations of proteins recently linked with energy homeostasis might be altered in acute AN (acAN), whether their levels are associated with reproductive hormones and whether they are restored after weight recovery. Our results show that activin A, follistatin, LH and estradiol concentrations are decreased while growth/differentiation factor-15 (GDF-15) concentrations are increased in 79 females with acAN before weight restoration (acAN_T1) compared to 79 healthy control females not receiving oral contraception (HC_OCP^-). The concentrations of all hormones were partially or completely restored after weight restoration by short-term ref

SUBMITTER: Ehrlich S 

PROVIDER: S-EPMC12916494 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature