Thalamic GABA+ levels are negatively associated with neuropsychiatric symptoms in patients with insomnia.

ABSTRACT:

Objective

Insomnia is the most common type of sleep disorder; however, the neurobiological causes and correlates of hyperarousal in insomnia remain to be fully determined, and the levels of cerebral metabolites in patients with insomnia remain unclear. This study aimed to quantify changes in cerebral metabolite levels in patients with insomnia and to explore their relationship with fatigue, anxiety, and subjective sleepiness.

Methods

Twenty unmedicated patients with insomnia disorder and 21 age- and sex-matched healthy volunteers were included. The concentrations of metabolites including γ-aminobutyric acid (GABA+), glutamate (Glu), glycerophosphocholine (GPC), creatine (Cr), and phosphocreatine (PCr) were obtained by magnetic resonance spectroscopy, and the differenc

SUBMITTER: Dai M 

PROVIDER: S-EPMC12916559 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature