Pentraxin 3 deficiency exacerbates neutrophilic inflammation and airway hyperresponsiveness in type 2-low asthma.

ABSTRACT:

Background

Type 2-low asthma is a severe, steroid-resistant phenotype characterized by neutrophilic inflammation and limited treatment options. PTX3, an acute-phase protein involved in innate immunity, has been linked to inflammatory diseases; but its role in type 2-low asthma remains unclear.

Methods

A chronic HDM + c-di-GMP murine model was used to mimic type 2-low asthma. PTX3^-/- and WT mice were assessed for inflammation, cytokine profiles, antibody responses, and lung function. AHR was measured using FlexiVent. BALF inflammatory cells were analyzed by cytospin and flow cytometry. Cytokines were quantified using mesoscale assay, and serum immunoglobulins by ELISA.

Results

In mice, the type 2-low model exhibited increased systemic and airway PTX3 levels.

SUBMITTER: Taefehshokr S 

PROVIDER: S-EPMC12916562 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature