Gut microbiota affects the progression of colorectal cancer under the intervention of exercise.

ABSTRACT: Colorectal cancer (CRC) ranks as the third most common cancer globally, accounting for 10% of cases, and is the second leading cause of cancer-related death. Exercise can maintain/restore the body's internal balance at multiple levels to prevent pathologies, although its mechanism is complex and involves multiple systems. While physical activity improves colon cancer patients' quality of life and reduces discomfort, how it works remains unclear. To explore this, we constructed a rat CRC model. We performed 16S rRNA and nontargeted metabolomics sequencing and analyzed the results to screen distinct intestinal microbes and their metabolites. To clarify the links among these microbes/metabolites, intestinal barrier function, and inflammatory markers, we used qRT-PCR, immunohistochemistry, and

SUBMITTER: Tao L 

PROVIDER: S-EPMC12916588 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature