Xiaoyao San alleviates emotional distress - induced TNBC growth through augmenting intratumoral CD8⁺T cell infiltration mediated by Rela/NF-kB-Cxcl9 axis.

ABSTRACT:

Background

Emotional distress (ED) is closely associated with the progression of triple-negative breast cancer (TNBC). Xiaoyao San (XYS), a classical Chinese herbal prescription traditionally used for mood regulation, has demonstrated potential therapeutic efficacy in emotion-related breast cancer. However, the molecular mechanisms through which XYS mitigates ED-induced TNBC (ED-TNBC) remain insufficiently characterized. This study aimed to investigate the therapeutic effects of XYS on ED-TNBC and elucidate its underlying molecular mechanisms.

Methods

A TNBC mouse model subjected to chronic unpredictable mild stress (CUMS) was developed to simulate ED-TNBC conditions. The therapeutic efficacy of XYS at varying doses was evaluated through behavioral assessments and tumor grow

SUBMITTER: Liang Y 

PROVIDER: S-EPMC12916637 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature