Impact of immune-related adverse events on treatment outcomes in advanced esophageal squamous cell carcinoma treated with immune checkpoint inhibitors.

ABSTRACT:

Background

While immune-related adverse events (irAEs) are associated with better prognosis in advanced esophageal squamous cell carcinoma (ESCC), the prognostic impact of single-organ irAE (uni-irAE), multiple-organ irAEs (multi-irAEs), and organ-specific irAEs remains poorly understood. This study aimed to address this gap by evaluating the effects of various irAEs on survival and characterizing the co-occurrence patterns of multi-irAEs in ESCC patients.

Methods

We retrospectively analyzed 213 ESCC patients treated with immune checkpoint inhibitor (ICI), dividing them into non-irAE, uni-irAE, and multi-irAEs groups to compare their efficacy and prognosis. Baseline characteristics and efficacy outcomes were compared by Chi-square test. Prognostic analysis was performed usin

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12916662 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature