Stem cell therapy targets THBS1 to reverse endometrial fibrosis.

ABSTRACT:

Background

Intrauterine adhesions (IUA) are a major cause of female infertility and recurrent pregnancy loss, characterized by endometrial fibrosis. The molecular mechanisms underlying IUA fibrosis are poorly understood. Thrombospondin-1 (THBS1), a matricellular protein linked to fibrotic disorders, has not been extensively studied in IUA. This study investigates the role of THBS1 in IUA pathogenesis and the therapeutic potential of decidua-derived mesenchymal stem cells (DMSCs), focusing on the PI3K/AKT signaling pathway.

Methods

Transcriptomic profiling identified significant upregulation of THBS1 in IUA tissues. Pathway analysis suggested that THBS1 promotes fibrosis via the PI3K/AKT pathway. In vitro and in vivo IUA models were used to evaluate fibrosis mar

SUBMITTER: Yu X 

PROVIDER: S-EPMC12916671 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature