STAT3 expression in brain metastases from breast cancer is correlated with molecular subtype and impacts clinical outcome.

ABSTRACT:

Background

A high pSTAT3 expression in reactive astrocytes surrounding brain metastases (BrM) promotes tumor growth in preclinical models. The impact of STAT3 expression on outcome of patients with BrM from breast cancer is unknown.

Methods

The expression of pSTAT3 in reactive astrocytes of 100 resected BrM from breast cancer was investigated by immunohistochemistry and correlated with molecular subtypes, risk of intracranial recurrence and progression-free survival. To explore whether clinical findings could be replicated in preclinical models, we used two human BrM cell lines (triple-negative MDA231 and HER2-positive HCC1954-), and evaluated pSTAT3 expression on established BrM.

Results

High pSTAT3 expression in reactive astrocytes was detected in 57% of BrM, and pr

SUBMITTER: Pellerino A 

PROVIDER: S-EPMC12916724 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature