Sepsis insult generates different vascular response phenotypes: an unsupervised time-series clustering preclinical study.

ABSTRACT: In this study, the temporal evolution of the cardiovascular response to sepsis was investigated by combining conventional hemodynamic parameters with novel indices derived from arterial blood pressure (ABP) waveforms that reflect vascular properties. The well-established association between sepsis and vascular dysfunction suggests that waveform-based indices may be instrumental in sepsis early detection and quantitative assessment of sepsis severity. ABP was continuously recorded at aortic and femoral sites in 40 pigs from a baseline condition to the full development of septic shock which was induced by intraperitoneal instillation of autologous feces. Standard beat-to-beat indices, including mean ABP, heart rate, and pulse pressure (PP), were computed alongside advanced cardiovascular mar

SUBMITTER: Vida I 

PROVIDER: S-EPMC12916789 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature