Time-dependent comparison of serum BDNF responses following high-intensity interval exercise and moderate- and low-intensity continuous exercise in healthy young men.

ABSTRACT: Exercise serves as a potent physiological stimulus influencing brain-derived neurotrophic factor (BDNF), a key molecule involved in neuronal maintenance, synaptic plasticity, and cognitive regulation. However, the temporal dynamics of circulating BDNF in response to varying exercise intensities remain poorly understood. This study investigated serum BDNF kinetics following low- and moderate-intensity continuous exercise (LICE, MICE) and high-intensity interval exercise (HIIE) in young healthy men. Twelve participants completed all three exercise sessions in a randomized crossover design with seven-day washouts. Venous blood samples were collected at baseline, immediately post-exercise, and at 5, 15, 30, 45, and 60 min of recovery. Serum BDNF and blood lactate concentrations were measured,

SUBMITTER: Birinci YZ 

PROVIDER: S-EPMC12916822 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature