FTO-dependent m⁶A Demethylation Activates Mxd1 To Enhance Vitamin D-induced Suppression of Neuroinflammation Via PTEN/AKT/PGC-1α Signaling Pathways in Microglia.

ABSTRACT: Neuroinflammation, driven primarily by activated microglia, is a key contributor to neurological disorders. A promising therapeutic approach involves reprogramming microglia from a pro-inflammatory (M1) to an anti-inflammatory (M2) phenotype. While vitamin D (VitD) has demonstrated immunomodulatory potential, its specific mechanisms in mitigating microglial inflammation are not fully understood. This study investigated the ability of VitD to reprogram lipopolysaccharide (LPS)-activated microglia toward an M2 phenotype and to elucidate the underlying molecular pathways. Our results demonstrated that VitD attenuated LPS-induced microglial activation and pro-inflammatory cytokine release in vivo, while simultaneously promoting M2 polarization in both in vitro and in vivo models. Mechanistical

SUBMITTER: Hu Z 

PROVIDER: S-EPMC12916930 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature