Representational differentiation and integration within the hippocampal circuit during naturalistic stimuli.

ABSTRACT: The hippocampus is essential for transforming dynamic experiences into structured knowledge, forming internal models of the world that guide planning, decision-making, and behavior. Recent research has demonstrated that complementary hippocampal mechanisms-specifically, the differentiation of distinct experiences and the integration of related information-fundamentally underlie cognitive map formation during spatial navigation. However, there is limited empirical evidence on how these processes support network-based, map-like representations during complex continuous stimuli. Here, using the Human Connectome Project 7T naturalistic dataset, we explored how the canonical hippocampal circuit (DG-CA3-CA1) supports differentiation and integration from movie stimuli. Our results found that the

SUBMITTER: Sun L 

PROVIDER: S-EPMC12916982 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature