Exosomes derived from bone marrow mesenchymal stem cells facilitate repair of radiation-Induced skin injury by attenuating inflammation and apoptosis.

ABSTRACT: Radiation-induced skin injury (RISI) refers to injury to the skin resulting from exposure to ionizing radiation, for which current treatment options are limited. Exosomes derived from bone marrow mesenchymal stem cells (BMSCs-Exos) have demonstrated significant potential in tissue repair. This study evaluated the healing efficacy of BMSCs‑Exos in a rat model of RISI. BMSCs-Exos were isolated and delivered via subcutaneous injection into the RISI. Our findings revealed that BMSCs-Exos reduced the wound area and lowered the radiation injury score, thereby indicating their capacity to facilitate RISI healing. Histological analysis revealed that BMSCs-Exos enhanced epidermal repair and collagen deposition. Immunological assays revealed significantly higher CD31 and α‑SMA expression of the BMSC

SUBMITTER: Wen Y 

PROVIDER: S-EPMC12916996 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature