Progranulin promotes glioma progression via interaction with cathepsin D and serves as a diagnostic and prognostic biomarker.

ABSTRACT: Progranulin (PGRN) plays a crucial role in the progression of various tumor types, making it a potentially valuable biomarker. However, the roles of PGRN vary across tumor types. Therefore, this study aimed to comprehensively analyze PGRN expression in different tumor types to better understand and apply biomarker-guided cancer therapy. The pan-cancer data were obtained from the University of California Santa Cruz Xena platform, and PGRN expression was extensively examined across various cancer types and the corresponding normal tissues. R packages were used for data analysis, including survival outcomes, baseline characteristic assessments, and univariate and multivariate Cox regression models to evaluate the prognostic significance of PGRN. Quantitative real-time polymerase chain reactio

SUBMITTER: Zhao C 

PROVIDER: S-EPMC12917043 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature