Regulation of Embryonic Wound Healing by Matrix Metalloproteinases in Xenopus laevis Tailbud Stage.

ABSTRACT: Scarless wound healing remains a key goal in regenerative research. However, the gene regulatory networks and mechanisms behind this process are still not fully understood, despite the use of high-throughput analyses and various research models. In our study, we focus on the intermediate phase and examine the role of remodelling genes called matrix metalloproteinases (MMPs) in the Xenopus laevis model. Through temporal bulk RNA-Seq analysis, we identified the fos/jun (AP-1) combination expressed during the early phase and four main mmps (1, 7, 8, and 9) expressed during the intermediate phase of healing. Using specific MMP inhibitors and morpholino-oligonucleotides targeting fos/jun, we found that mmp expression depends on stress response and that they are crucial for embryonic wound heali

SUBMITTER: Kraus D 

PROVIDER: S-EPMC12917100 | biostudies-literature | 2026 Jan-Feb

REPOSITORIES: biostudies-literature