Incidence of meningioma in women with a history of combined oral contraceptive pill use and polycystic ovary syndrome.

ABSTRACT:

Background

Meningiomas, benign central nervous system tumors, express progesterone and estrogen receptors. Their proliferation has been associated with hormonal and demographic factors, including female sex, obesity, and race. Prior studies on oral contraceptive pill (OCP) use and meningioma risk have been limited in their analysis of the modifying effects of race, obesity, and polycystic ovary syndrome (PCOS).

Objectives

To assess the association between combined OCP use and meningioma development, and to assess how race, obesity, and PCOS influence this relationship.

Design

Retrospective cohort study using aggregated electronic health record data in Epic Cosmos.

Methods

Women aged 13-50 from 2005 to 2023 with and without combined OCP use were identified. Pati

SUBMITTER: Edwards E 

PROVIDER: S-EPMC12917173 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature