Long-Term Adherence and Drug Utilisation Patterns Among New Users of Anti-Hyperlipidemic Monotherapy: Development of a Risk Prediction Model.

ABSTRACT:

Rationale

Real-world long-term adherence and drug patterns are essential in hyperlipidemia management. However, the evidence was unclear.

Aims and objectives

This study aimed to assess long-term adherence, drug usage patterns of anti-hyperlipidemic monotherapy, associated risk factors, and develop risk prediction models.

Methods

We performed a retrospective inception cohort study utilising data from the University of Groningen's IADB.nl dispensing database. The study included new users of anti-hyperlipidemic monotherapies-simvastatin, pravastatin, fluvastatin, atorvastatin, rosuvastatin, and fibrates, with approximately a follow-up to 10 years. Using logistic regression, we developed risk prediction models for adherence and drug utilisation patterns, including discont

SUBMITTER: Li X 

PROVIDER: S-EPMC12917296 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature