Association between maternal dietary isoflavone consumption during pregnancy and childhood food allergy in offspring: The Japan Environment and Children's study.

ABSTRACT:

Background

Isoflavone (ISO) consumption during pregnancy may affect food allergy (FA) in offspring through estrogen-like and other biological effects; however, this ISO-FA association in mother-child pairs remains elusive. Herein, the maternal ISO-childhood FA association was investigated using the Japanese birth cohort data.

Methods

The data from the Japan Environment and Children's Study, including 86,012 and 75,307 mother-child pairs, with FA in children aged ≤1 year and 1-3 years, respectively, were analyzed. Maternal ISO consumption (total daidzein and genistein) was assessed using a food frequency questionnaire. Physician-diagnosed FA data were obtained using questionnaires completed by caregivers. ISO consumption data was categorized into quartiles (Q1: reference), an

SUBMITTER: Yang G 

PROVIDER: S-EPMC12917298 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature