Dietary animal fat disrupts gut microbiota and aggravates Scl-cGVHD after allogeneic hematopoietic stem cell transfer.

ABSTRACT:

Abstract

Allogeneic hematopoietic stem cell transplant (allo-HSCT) is an effective treatment for high-risk or relapsed acute leukemia. However, the frequent occurrence of graft-versus-host disease (GVHD) poses significant complications. Modifiable factors such as the gut microbiome and dietary regimen have the potential to influence the frequency and severity of GVHD. Previous studies in mouse models have shown a direct link between obesity and increased severity of GVHD; however, analysis of human data has not suggested a causal relationship. We hypothesized that dietary fat content before transplantation, rather than obesity itself, might affect outcomes, given that increased dietary fat is associated with reduced gut microbiome diversity. In our study, we evaluated the effects o

SUBMITTER: Millick DD 

PROVIDER: S-EPMC12917525 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature