Anatomical phenotyping and staging of brain arteriovenous malformations.

ABSTRACT: Brain arteriovenous malformations (AVMs) are potentially life-threatening vascular anomalies that pose significant clinical challenges due to their heterogeneous anatomy and unpredictable natural history. Existing risk stratification models largely rely on isolated imaging markers and fail to account for the dynamic spatial-temporal complexity of AVMs. Building on our prior work, demonstrating how ontogenesis dictates clinical outcomes of neuroepithelial tumours, we hypothesize that AVMs are similarly influenced by developmental processes that define their spatial distribution, vascular architecture and susceptibility to complications. Here, we present the protocol and pilot data of our multicentre, retrospective and prospective observational study, which introduces a multidimensional appr

SUBMITTER: Beyersdorf B 

PROVIDER: S-EPMC12917541 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature