Establishing reference intervals for 25 common biochemical analytes in Tibetans living at very high altitude.

ABSTRACT:

Objectives

High altitude poses extreme living environment for humans, impacting human physiology and leading to physiological adaptations, including higher hemoglobin levels in highlanders. However, further understanding is required regarding the medical reference ranges at very high altitudes (>4,500 m). Therefore, we conducted a study involving 1,656 healthy individuals from the "Health Improvement at Very High Altitude (HI-VHA)" population to establish a reference range for 25 biochemical analyses in this population residing at very high altitudes.

Methods

The HI-VHA project sampled 3,564 individuals from Tibet Autonomous Region above 4,500 m. After strict exclusion criteria, 1,656 healthy individuals were included to establish age and sex stratified reference intervals (

SUBMITTER: Ci B 

PROVIDER: S-EPMC12917553 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature