Inhibition of IRE1α kinase increases ferroptosis resistance in triple-negative breast cancer cells.

ABSTRACT: Ferroptosis is a regulated form of cell death that serves a pivotal role in tumor suppression. Whilst the ribonuclease activity of inositol-requiring enzyme 1α (IRE1α) is associated with the regulation of ferroptosis, the potential involvement of its kinase domain in this process remains elusive. Thus, the present study aimed to investigate the specific role of the IRE1α kinase domain in regulating ferroptosis in breast cancer, particularly in the triple-negative breast cancer (TNBC) subtype. To this end, it employed a combination of bioinformatic analysis of clinical datasets, pharmacological inhibition of IRE1α kinase and genetic overexpression models in TNBC cell lines. The present study demonstrated that endoplasmic reticulum to nucleus signaling 1 (ERN1; the gene encoding IRE1α

SUBMITTER: Xu S 

PROVIDER: S-EPMC12917570 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature