Mouse genome engineering uncovers 18 genes dispensable for male reproduction.

ABSTRACT:

Background

Male infertility is an intricate multifactorial disease involving the interplay between genetic and environmental factors. Genetic anomalies account for more than 15% of all male infertility cases; however, diagnosing them exhibits enormous challenges due to variable symptomatic presentations and limited knowledge of gene functions. Therefore, a thorough investigation into gene regulatory networks underlying male reproduction is demanded to improve patient counseling and infertility treatment.

Objective

In this study, we aimed to identify testis-expressed genes essential for male fertility.

Methods

We searched public databases, such as the National Center for Biotechnology Information (NCBI), Ensembl genome browser, the Human Protein Atlas (HPA), and the Ma

SUBMITTER: Chang HY 

PROVIDER: S-EPMC12917576 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature