Decoding the interplay between protic ionic liquids and drug: spectrophotometric, electrochemical, and DFT exploration of mitoxantrone.

ABSTRACT: Thus far, ILs have attracted growing interest in pharmaceutical applications due to their systematic variation of physicochemical properties that can be tailored to overcome the relevant formulation hurdles associated with poorly soluble and unstable drugs. Beyond solvents, ILs could serve as media for stabilization or even as co-excipients to provide a versatile matrix for enhanced drug performance with decreased side effects. Although most anthracycline antibiotics, such as daunomycin and adriamycin, are cardiotoxic, others, such as mitoxantrone (MTX), are effective and less cardiotoxic. Because it has a planar tricyclic chromophore, MTX, with its protonated side chains, could potentially be involved in dynamic noncovalent interactions, particularly at the level of nucleic acids. In this

SUBMITTER: Sharma A 

PROVIDER: S-EPMC12917589 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature