A comparative study on phytochemical analysis and biological properties of three varieties of <i>cannabis sativa L. seeds</i>.

ABSTRACT: This study evaluated the antioxidant, anti-inflammatory, and analgesic properties of three varieties of Cannabis sativa L. seeds from Morocco, alongside their chemical compositions. High-Performance Liquid Chromatography with Diode Array Detection (HPLC-DAD) were employed for chemical analysis. Antioxidant activity was assessed using ABTS, TAC, and ferric reducing antioxidant power (FRAP) assays, while anti-inflammatory and analgesic effects were tested in animal models. Molecular docking targeted 5IKQ and 3RP8 enzymes based on HPLC-identified compounds. The hydroalcoholic extracts demonstrated appreciable levels of phenolics and flavonoids: total phenolic content (TPC) was 76.87 ± 0.24 mg GAE/g DW (Cric), 81.45 ± 1.37 mg GAE/g DW (Khard), and 84.96 ± 2.05 mg GAE/g DW (Beldiya), whi

SUBMITTER: El-Mernissi R 

PROVIDER: S-EPMC12917594 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature