Transition Metal Complex Based On Phenoliccarboxylic Ligand: Spectroscopic Inspection, DFT/TDDFT Computations, Cytotoxicity and Molecular Docking Investigation.

ABSTRACT: The study was designed to explore the synthesis, characterization, and biological evaluation of a novel Mn-(II)-3-[(3-carboxy-2-hydroxyphenyl)-methyl]-2-hydroxybenzoic complex, [Mn-(CHB-2H)·4H₂O)]·2H₂O, in comparison to its corresponding ligand (CHB). The manganese-(II) complex (Mn-(II)-CHB) was synthesized from CHB and manganese-(II) acetate in ethanol solution using the conventional method. Because most of the chemo drugs are nonselective and may cause damage to normal tissues, finding new anticancer medications or developing anticancer agents is becoming more crucial. The work's objective was to minimize the toxic side effects of most chemo drugs and improve available chemotherapy against human liver cancer. PXRD, TEM, thermal (TGA, DSC), magnetic investigations, U

SUBMITTER: Ahmed AH 

PROVIDER: S-EPMC12917707 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature