Activity-Selectivity of Flavonoid Derivatives in Endometriotic Cells.

ABSTRACT: Natural polyphenolics, more specifically flavonoids and derivatives, constitute chemically versatile scaffolds with a broad biological potential. In this study, different flavonoid derivatives (1-37) were assessed for cytotoxicity in Ishikawa and 12Z epithelial cell lines, serving as models of eutopic endometrium and endometriosis, respectively, to elucidate structure-activity relationships. Flavonoids bearing multiple hydroxyl and methoxy substituents exhibited high polarity, an elevated topological polar surface area (TPSA), and numerous hydrogen-bond donors and acceptors, consistently demonstrating low cytotoxicity and, in several cases, cytoprotective effects. In contrast, chalcones containing electron-withdrawing substituents (-NO₂ and -Cl) and higher lipophil

SUBMITTER: Gomes KS 

PROVIDER: S-EPMC12917715 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature