Non-Invasive Pancreas Ablation Using Histotripsy: Pre-clinical Safety Study in an In Vivo Porcine Model.

ABSTRACT: Pancreatic cancer is an aggressive disease that is typically diagnosed late, leading to poor prognosis and overall survival. Even with advances in treatment, the 5-year survival rate for patients is only 12.5%. Histotripsy is a non-invasive, non-thermal and non-ionizing focused ultrasound treatment method that has recently been US FDA approved for treating liver tumors and is currently being investigated for other applications. This study expands on prior work investigating the feasibility of pancreas ablation using ultrasound-guided histotripsy in pigs. Here, we applied histotripsy to healthy pancreas in nine pigs using a therapy system with treatments guided by real-time ultrasound imaging. After treatment, subjects survived for 1 week (n = 3) or 5 weeks (n = 6). Damage to the pancreas a

SUBMITTER: Gannon J 

PROVIDER: S-EPMC12917764 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature