Design of Highly Specific Antimicrobial Peptides Targeting the BamA Protein of <i>Candidatus</i> Liberibacter Asiaticus.

ABSTRACT: Candidatus Liberibacter asiaticus (CLas) is a putative causative agent of Huanglongbing (citrus greening). The unculturable nature of CLas poses a significant challenge in discovering drugs against citrus greening. This study presents a novel in silico technique to design peptides with a high affinity toward the β-barrel assembly machinery A (BamA) protein, a critical outer membrane component of CLas vital for bacterial functionality. The technique used in this study is based on identifying the strongest binding amino acids at different sites in BamA and linking them using peptide linkers. Initially, amino acid probes that can emulate amino acid activity in peptide form were docked using Schrodinger Glide on the target domain of BamA. Docking results of amino acid probes showed thre

SUBMITTER: Mallawarachchi S 

PROVIDER: S-EPMC12917781 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature