Anticonvulsant Potential of the Essential Oil of <i>Croton Heliotropiifolius</i> Kunth: In Vivo and In Silico Approach.

ABSTRACT: Epilepsy is a chronic condition that significantly impacts the quality of life of many individuals, underscoring the urgent need for the identification of safe and effective anticonvulsant agents. In this context, medicinal plants have emerged as a promising source of bioactive compounds for treating epilepsy. This study involved an in vivo and in silico investigation of the anticonvulsant activity of the essential oil from the leaves of Croton heliotropiifolius Kunth (OCH). In vivo experiments revealed that the essential oil promoted a significant increase in seizure latency and survival rate in animals treated with OCH at a dose of 200 mg/kg, indicating an anticonvulsant effect. To understand the possible receptors and sites of action of the compounds in the oil, we performed a mo

SUBMITTER: da Cunha MES 

PROVIDER: S-EPMC12917805 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature