Development of a Simple and Efficient Method for the Micropatterning of Silk Fibroin.

ABSTRACT: Microfabrication is a crucial tool for designing tissue scaffolds, biosensors, and implantable devices with complex, precisely defined shapes and surface topographies. Among all available techniques, photolithography is scalable and economical, and it produces micron-level resolution. Silk fibroin (SF), extracted from silk cocoons, has shown promise in wound healing and tissue repair applications due to its biocompatible, sustainable, and low-immunogenic nature. This study aimed to identify an optimal photolithography-based method for the microfabrication of silk fibroin (SF), which is scalable and reproducible. The study microfabricated the methacrylate SF (SFMA) patterns on silicon wafers and characterized their physicochemical, morphological, mechanical, cytotoxic, and biological proper

SUBMITTER: Choudhary HB 

PROVIDER: S-EPMC12917831 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature