Functional Genomics Studies of Psychiatric Disorders in Individuals of Latin American Populations: A Scoping Review.

ABSTRACT: Over the past 15 years, genetic studies of psychiatric disorders have provided important insight into the contribution of both common variants of small effect, as well as rare exonic and copy number variants with large effect sizes. Genome-wide association studies (GWAS) allow us to understand the intricate polygenicity characteristic of many psychiatric disorders. However, a considerable proportion of single nucleotide polymorphisms (SNPs) implicated in these disorders localize to the non-coding regions of the genome. Unraveling the molecular mechanisms that underlie the etiology of psychiatric illnesses requires integration using functional genomics approaches. Functional genomics methods are critical for developing a mechanistic understanding of genetic findings in psychiatric disorders

SUBMITTER: Porras LM 

PROVIDER: S-EPMC12917904 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature