Dual Treponemal and Non-Treponemal Rapid Test for Syphilis in People Living with HIV: A Diagnostic Accuracy Study.

ABSTRACT:

Background

Rapid dual treponemal/non-treponemal (lipoidal antigen) tests could improve syphilis detection strategies among people living with HIV (PLHIV). The World Health Organization (WHO) recommends minimum performance targets for syphilis point-of-care tests: sensitivity >80% for the treponemal component, >95% for the non-treponemal component, and specificity >90% for both. We evaluated the diagnostic accuracy of a dual treponemal/non-treponemal test in PLHIV.

Methods

Cross-sectional study using stored serum samples donated by PLHIV who had been previously enrolled in a study conducted in Cali, Colombia. The index test was the Dual Path Platform® Syphilis Screen & Confirm Assay (DPP-SSCA, Chembio Diagnostic Systems, Inc.). A combination of Treponema pallidum haemagglutin

SUBMITTER: Fuertes-Bucheli JF 

PROVIDER: S-EPMC12917955 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature