Clinical and economic evaluation of risk factor guided respiratory syncytial virus prophylaxis in Colombian preterm infants.

ABSTRACT:

Background

The International Risk Scoring Tool (IRST) comprises three risk factors (age relative to the respiratory syncytial virus [RSV] season; household and/or maternal smoking; siblings and/or daycare attendance) and enables the cost-effective targeting of palivizumab to infants born at 32-35 weeks' gestational age (wGA) at greatest risk of related hospitalization (RSVH). This study provides the first evaluation of IRST-guided RSV prophylaxis in Colombia.

Methods

The IRST (with wGA substituted for chronological age as RSV is endemic in Colombia) plus other risk factors were assessed using data from 81 infants born 32-35 wGA with RSVH and 49 gestational- and age-matched controls. A cost-utility model comparing IRST-guided palivizumab versus no prophylaxis from the healthc

SUBMITTER: Rodriguez-Martinez CE 

PROVIDER: S-EPMC12918000 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature