Lactate clearance predicts massive transfusion in upper gastrointestinal bleeding: a single-center retrospective study.

ABSTRACT:

Objectives

Lactate clearance (LC) has emerged as a potential prognostic marker in critically ill patients. However, its role in predicting massive transfusion (MT) requirements in upper gastrointestinal bleeding (UGIB) patients remains unclear. This study aimed to evaluate the predictive value of LC for MT requirements in patients with UGIB.

Methods

This retrospective study included 452 patients diagnosed with UGIB between September 2021 and September 2023. Patients were divided into MT and non-MT groups, with MT defined as ≥ 10 units of red blood cell transfusion within 24 h or ≥ 4 units within 1 h. LC was calculated as [(Initial lactate - 1-hour lactate)/Initial lactate] × 100. Appropriate statistical analyses were performed to evaluate the predictive value of LC for MT.

SUBMITTER: Yortanlı BC 

PROVIDER: S-EPMC12918077 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature