CircCCDC66 promotes the progression and EMT of renal cell carcinoma via the miR-1278/HOXA13 axis.

ABSTRACT:

Background

Renal cell carcinoma (RCC) is a common lethal malignancy of the urinary system with a complex pathogenesis. Among its subtypes, clear cell renal cell carcinoma (ccRCC) represents the predominant pathological type. Circular RNAs (circRNAs), a class of covalently closed RNA molecules, play critical roles in various cancers. CircCCDC66 has been reported to exhibit aberrant expression and participate in tumor progression in multiple malignancies; however, its functional role and underlying mechanisms in clear cell renal cell carcinoma (ccRCC) remain unclear. This study aimed to investigate the role of circCCDC66 in ccRCC and its underlying regulatory mechanism.

Methods

CircCCDC66, miR-1278, and HOXA13 expression levels in ccRCC tissues and cell lines were measured usi

SUBMITTER: Peng Z 

PROVIDER: S-EPMC12918117 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature