Etiological characteristics and risk factors for severe disease in bocavirus-associated community-acquired pneumonia in children: a multicenter retrospective study.

ABSTRACT:

Objective

This is a multicenter retrospective study aimed to evaluate the concordance between nucleic acid testing and targeted next-generation sequencing (tNGS) for etiologic detection, and to identify potential risk factors for severe community-acquired pneumonia (SCAP), thereby providing evidence for precision clinical management.

Methods

We retrospectively analyzed 191 pediatric Community-Acquired Pneumonia(CAP) cases positive for bocavirus by tNGS from April 2023 to June 2025. Etiologic concordance and coinfection patterns were evaluated. Univariate and multivariate logistic regression identified independent risk factors for SCAP.

Results

191 children were included. Significant heterogeneity was observed among the four centers in age distribution, SCAP incidence,

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12918134 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature