<i>In vitro</i> phenotypically stable cartilage regeneration with mechanically adaptable microenvironment using a hydrostatic pressure bioreactor.

ABSTRACT: The regenerative repair of diverse cartilage injuries is a remarkable clinical challenge. Recently, hydrogel-based tissue engineering strategy offers an alternative treatment for cartilage defect repair. However, in vitro cartilage pre-culture period is often confronted with predicaments of insufficient nutrition transport and cartilage phenotypic instability. Inspired by natural mechanical microenvironment of articular cavity, our group has pioneered a hydrostatic pressure (HP) bioreactor for cartilage regeneration. Herein, we present an in vitro hydrostatic bioreactor method using porous hydrogel scaffolds for accelerating phenotypically stable cartilage regeneration. In this study, 3D-printed porous gelatin/chondroitin sulfate composite hydrogel scaffolds exhibit favorable

SUBMITTER: Qiu C 

PROVIDER: S-EPMC12918173 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature