ROS-responsive hydrogel patch orchestrating macrophage reprogramming and mitochondrial protection for post-MI repair.

ABSTRACT: Myocardial infarction (MI) leads to irreversible cardiomyocyte loss accompanied by oxidative stress, inflammation, and fibrotic remodeling, ultimately progressing to heart failure. Using network pharmacology analysis, salvianolic acid B (DB), a major bioactive component of Salvia miltiorrhiza, was identified as a promising therapeutic candidate for MI. Oral administration of DB showed therapeutic efficacy in functional, molecular, and histological assessments, but its clinical translation is limited by poor bioavailability. To overcome this limitation, we developed an injectable reactive oxygen species (ROS)-responsive hydrogel patch for localized MI repair. The hydrogel, composed of whey protein isolate methacrylate (WPI-MA) and o-nitrobenzyl alcohol modified hyaluronic acid (HA-NB

SUBMITTER: Li M 

PROVIDER: S-EPMC12918174 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature