Dataset Information
Modulation of an aberrant basal cell program in human alveolar epithelial spheroids and lung slices.
Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC12918232 | biostudies-literature | 2025 Dec
REPOSITORIES: biostudies-literature
Publications
Modulation of an aberrant basal cell program in human alveolar epithelial spheroids and lung slices.
Respiratory research 20251212 1
RATIONALE: Idiopathic Pulmonary Fibrosis (IPF) is a progressive scarring disease marked by the accumulation of aberrant basal cells that are thought to promote disease progression. The cellular origin and disease-relevant cues that lead to aberrant basal cells remain poorly understood. OBJECTIVES: We sought to identify the signals regulating formation and maintenance of aberrant basal cells from human alveolar type II (ATII) cells using 3D spheroids, and test whether inhibition of select pathway ...[more]
